Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep42 | Adrenal and Cardiovascular Endocrinology | ECE2023

Circadian fluctuations of acylcarnitines and sphingomyelins when measured in serum and in dried blood spots

Bissi Valentina , Improta Ilaria , Galante Greta , Tucci Lorenzo , Vicennati Valentina , Pagotto Uberto , Dalmazi Guido Di , Fanelli Flaminia

Background: Acylcarnitines and sphingomyelins are key players of lipid metabolism at cytosolic, vesicular and cell membrane level. Their metabolism was found deranged in diseases of the hypothalamus-pituitary-adrenal axis. Little information is available about levels of these compounds in the bloodstream and their circadian fluctuations. Dried blood spots (DBS) allow multiple autonomous and painless collections per day. However, poor biological validation data are available ab...

ea0090ep70 | Adrenal and Cardiovascular Endocrinology | ECE2023

Glycerophospholipid circadian profiles in serum and dried blood spot in healthy subjects

Galante Greta , Bissi Valentina , Improta Ilaria , Tucci Lorenzo , Vicennati Valentina , Pagotto Uberto , Dalmazi Guido Di , Fanelli Flaminia

Introduction: Lipidomics is an emerging approach to characterize circadian rhythm alterations due to diseases of the hypothalamus-pituitary-adrenal axis. Glycerophospholipids are membrane structural constituents and key players in cell signalling, homeostasis and inflammatory and immune responses. Among blood derivatives, serum may reflect the soluble fraction, whereas dried blood spot (DBS) may reflect the cell membrane fraction of these lipids. However, little information is...

ea0090ep400 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Circadian profiles of amino acids and biogenic amines in serum and dried blood spot assessed by LC-MS/MS in healthy subjects

Improta Ilaria , Bissi Valentina , Galante Greta , Tucci Lorenzo , Vicennati Valentina , Pagotto Uberto , Fanelli Flaminia , Dalmazi Guido Di

Introduction: Recent studies demonstrated that circulating concentration of many metabolites fluctuates with circadian rhythmicity. However, detailed information on amino acid and biogenic amine daily variations is still lacking. Dried blood spot (DBS) sampling appears to be a convenient tool for studies requiring multiple daily sampling.Aim: To verify the validity of DBS as a suitable device, we compared serum and DBS levels and changes along the day of...

ea0090oc9.1 | Oral Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Identification of adrenocortical masses malignancy and aggressivity through radiomics: a pilot study

Tucci Lorenzo , Vara Giulio , Improta Ilaria , Leo Antonio De , Selva Saverio , Balacchi Caterina , Santini Donatella , Mosconi Cristina , Vicennati Valentina , Pagotto Uberto , Dalmazi Guido Di

Background: Adrenal lipid poor adenoma (LPA) and adrenocortical cancer (ACC) may overlap in computerized tomography (CT). Radiomics recently emerged as new tool for malignant behavior identification.Aim: To assess radiomics utility for identification of ACC and LPA in adrenocortical masses with unenhanced (UE) CT scan attenuationā‰„10 Hounsfield Unit (HU).Methods: We retrospectively enrolled 50 patients, 38 radiologically defin...

ea0090p559 | Adrenal and Cardiovascular Endocrinology | ECE2023

Anxiety, depression, quality of life and sleep: new insights in adrenal insufficiency care through salivary cortisol and cortisone diurnal rhythm measurement

Tucci Lorenzo , Vicennati Valentina , Bissi Valentina , Galante Greta , Colombin Giacomo , Coscia Kimberly , Improta Ilaria , Rotolo Laura , Fanelli Flaminia , Pagotto Uberto , Di Dalmazi Guido

Background: Adrenal insufficiency patient (AIP) care is mostly based on symptoms or clinical signs of inadequate glucocorticoid replacement treatment (GRT). Salivary cortisol (F) and cortisone (E) recently emerged as new tools for AIP management, although poorly employed in clinical practice.Aim: To assess associations between salivary glucocorticoid measures and life quality, anxiety depressive symptoms, sleep quality in AIP.Metho...

ea0093oc21 | Oral communication 3: Adrenal Tumors and Neuroendocrine Tumors | EYES2023

Identification of adrenocortical masses malignancy through radiomics: A pilot study

Tucci Lorenzo , Vara Giulio , Improta Ilaria , De Leo Antonio , Selva Saverio , Balacchi Caterina , Santini Donatella , Mosconi Cristina , Vicennati Valentina , Pagotto Uberto , Di Dalmazi Guido

Background: Adrenal lipid poor adenoma (LPA) and adrenocortical cancer (ACC) may overlap in computerized tomography (CT). Radiomics recently emerged as new tool for malignant behavior identification.Aim: To assess radiomics utility for identification of ACC and LPA in adrenocortical masses with unenhanced (UE) CT scan attenuationā‰„10 Hounsfield Unit (HU).Methods: We retrospectively enrolled 50 patients, 38 radiologically defin...

ea0093oc47 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Amino acids and biogenic amines circadian fluctuation in health and in hypercortisolism states

Galante Greta , Tucci Lorenzo , Improta Ilaria , Bissi Valentina , Perrone Alessandro , Coscia Kimberly , Colombin Giacomo , Di Cintio Ilaria , Vicennati Valentina , Pagotto Uberto , Di Dalmazi Guido , Fanelli Flaminia

Background: Chronic hypercortisolism exhibits irregular circadian rhythm and deranged protein metabolism. Altered amino acid(AA) and biogenic amine(BA) circulating levels were found in patients with hypercortisolism. However, there is limited information about the physiologic circadian fluctuation of AA and BA levels, and it is not known whether this is affected by states of hypercortisolism.Aim: To characterize levels and daily fluctuations of AA and BA...

ea0099p15 | Adrenal and Cardiovascular Endocrinology | ECE2024

Dysregulation of salivary cortisol rhythm in non-secreting and mild cortisol-secreting adrenal incidentalomas

Coscia Kimberly , Fanelli Flaminia , Tucci Lorenzo , Bissi Valentina , Galante Greta , Improta Ilaria , Donnarumma Francesca , Colombin Giacomo , Rotolo Laura , Lena Claudia , Noreen Sobia , Vicennati Valentina , Pagotto Uberto , DiDalmazi Guido

Background: Adrenal incidentalomas (AI) are classified into mild autonomous cortisol-secreting (MACS) and non-secreting (NS) based on the 1mg-dexamethasone suppression test (DST). However, the latter test fails to detect alterations in the cortisol rhythm, which might be present in both MACS and NS.Aim: To characterize the cortisol secretion in terms of daily rhythm and exposure in healthy controls (HC) and patients with AI.Methods...

ea0099ep325 | Adrenal and Cardiovascular Endocrinology | ECE2024

Circadian fluctuation of amino acids and biogenic amines in health and in hypercortisolism states

Di Dalmazi Guido Fanelli Flaminia , Tucci Lorenzo , Bissi Valentina , Galante Greta , Improta Ilaria , Perrone Alessandro , Coscia Kimberly , Colombin Giacomo , Vicennati Valentina , Pagotto Uberto , Di Dalmazi Guido

Background: Chronic hypercortisolism is known to alter the circadian rhythm and to impair protein metabolism. Altered amino acid (AA) and biogenic amine (BA) levels were found in basal blood in patients with hypercortisolism. However, poor information is available on the physiologic circadian fluctuation of these molecules. Furthermore, the potential derangement caused by hypercortisolism was never investigated.Aim: To characterize diurnal levels and flu...

ea0099oc11.3 | Oral Communications 11: Adrenal and Cardiovascular Endocrinology | Part II | ECE2024

Prediction of adrenal masses nature through texture analysis and deep learning: Preliminary results from ENS@T RADIO-AI multicentric study

Tucci Lorenzo , Vara Giulio , Morelli Valentina , Menendez Torre Edelmiro Luis , Dischinger Ulrich , Markou Athina , Terzolo Massimo , Spyroglou Ariadni , Parazzoli Chiara , Carmen Aresta , Chiodini Iacopo , Rivas Diego , Gutierrez Alba , Schlotelburg Wiebke , Alexandraki Krystallenia , Puglisi Soraya , Improta Ilaria , De Leo Antonio , Selva Saverio , Alberici Laura , De Giglio Andrea , Pantaleo Maria Abbondanza , Balacchi Caterina , Mosconi Cristina , Vicennati Valentina , Pagotto Uberto , Di Dalmazi Guido

Background: Current parameters of conventional radiology have several limitations in defining the nature of adrenal masses. Radiomics, or texture analysis, has shown high diagnostic performance in recent pilot studies, although confirmatory studies are needed. Moreover, the effect of combination of radiomics with hormonal secretion on diagnostic performance is poorly explored.Aim: To evaluate the accuracy of radiomics in predicting adrenal masses nature ...